Monday, August 7, 2006

Dogs can be trained to detect early and late stages of lung and breast cancer accurately according to a study published by California scientists in the little-known scientific journal Integrative Cancer Therapies.

The study took place over the last five years at the Pine Street Foundation, a non-profit organization which conducts evidence-based research on integrative medicine (combining complementary and alternative medicine and mainstream medicine). Michael McCulloch and colleagues used three Labrador Retrievers and two Portuguese Water Dogs, both common pets, that received basic behavioral dog training. The researchers trained the dogs to lie down next to a sample from a cancer patient and to ignore other samples.

The samples used were breath samples from 55 patients with lung cancer and 31 with breast cancer — the two types of cancer with the highest mortality rates in the United States.

After the training phase, the dogs’ accuracy diagnosis was tested in a double-blind experiment. Among lung cancer patients, the sensitivity and specificity were 99% accurate and for breast cancer sensitivity was 88% and specificity 98%. Because these figures seem almost too good to be true, cancer experts are the same time baffled and skeptical. The authors of the study themselves also say replication of the study is needed.

Importantly, this was independent of the cancer stage, meaning the dogs were able to pick up the scent of cancer in its early stages. This is important because in many cases, the success of any treatment depends on early diagnosis. However, the researchers don’t believe this will lead to the use of dogs in the clinic soon, rather they want to find out which chemicals are actually sensed by the canines, because they could be used in laboratory assays. “It’s not like someone would start chemotherapy based on a dog test,” Dr. Gansler of the American Cancer Society said, “They’d still get a biopsy.”.

The researchers were inspired by anecdotal reports about dogs detecting cancer. In 1989, a British women consulted with her family physician because her Dalmatian kept licking a mole on her leg. At biopsy it showed to be malignant melanoma. When diagnosed too late this form of cancer has a poor survival rate, but in this case early surgery was made possible, and the women survived. Prior studies showed that breath samples from patients with lung cancer or breast cancer contain distinct biochemical markers. This provides a basis for the hypothesis that some cancer types produce volatile chemicals that dogs could smell. A study published in the British Medical Journal already proved that dogs could use their exquisite sense of smell to detect bladder cancer in urine samples, but they were only correct in 41% of cases, and another study provided preliminary evidence that dogs could detect melanomas.

This doesn’t mean you can show your breasts to your dog and it will tell you if you have cancer, other physicians caution, and scientists do not advise people to train their dogs to sniff for cancer. Unresolved issues from the study include the fact that subjects were required to breathe deeper than normal, so it’s not sure whether dogs can smell cancer in normal breath. Also, whether this is a permanent skill that would be retained by dogs was not tested.

Finally, there are concerns that could arise over liability issues: who would be responsible when the dog makes a mistake?

Current detection methods for both lung and breast cancer are not flawless. For lung cancer, chest X-ray and sputum cytology (detecting cancer cells in coughed up fluid) fail to detect many early cases, and CT scan produces many false-positive results unless combined with expensive PET scans. Although it might be comparing apples and oranges, a $2.5 million CT scanner has an accuracy of 85 to 90%. Mammography also produces false-positive results, and it may be difficult in women with dense breast tissue. As such, another type of “pet”-scan, using dogs as a biological assay, might prove feasible for screening if supported by further research. Current tests are also expensive so the use of dogs for preliminary cancer testing could prove to be an affordable alternative for countries in the developing world.

Thursday, November 8, 2007

The sale of the BBC subsidiary BBC Resources Ltd., has hit a hurdle after it emerged that the BBC could be left with a loss of up to £15 million on the deal. The cost of transferring the pensions of BBC Resources staff from the BBC pension scheme to its new owners could be up to £50 million according to a Guardian Newspaper report.

Managers from the division will meet with union representatives from BECTU on Monday to discuss this and related sale issues. BECTU general secretary, Gerry Morrissey is quoted as saying: “If the BBC gets less than £50 million for BBC Resources then how can it fulfil [sic] its duty of care to licence fee payers?”

It is believed that the BBC had hoped that a surplus in its pension fund could be used to bridge the possible £50 million gap — but the trustees of the fund have said “no”. A BBC source said: “This is being discussed at the highest level”.

Since April 2004 members of the BBC pension scheme have seen their contributions into it increase regularly, the BBC — like many other employers — having reduced its contribution (to 4.5% of payroll) over a ten year period when the stock market was booming in the 1990s.

The Guardian is seen as a reliable source on BBC matters, having reported the proposed sale of BBC Television Centre back in January 2007, with the formal announcement finally being made by BBC Director General Mark Thompson on October 18, 2007.

The Resources business-to-business unit was formed in 1998 and operates television studios, post-production and outside broadcast facilities for it’s parent share-holding company, the BBC. It does not own any studios or premises, its assets being staff and equipment.

Advertised for sale on 16th August in the Financial Times, The Times and Broadcast and last year making profits of £5.2 million with a revenue of £126 million, the disposal — led by Ernst & Young — invited expressions of interest for the whole division or for each of its three operations separately. The BBC has yet to release the names of the short-listed companies.

BBC Resources was the first of the BBC’s commercial business-to-business divisions to be set up as a limited company and will be the last to be sold, the BBC having previously divested itself of BBC Technology and BBC Broadcast — BBC Worldwide, formerly BBC Enterprises, will remain in-house as it earns revenue from the archive, media and licensing of products — in the year to 31 March 2007 Worldwide had a turnover of £810.4 million, generating profits of £111 million.

The BBC wants to use any money raised to be put into international commercial expansion and content, most probably through Worldwide.

It had been intended to float Resources back in 2005, but this was postponed for two years following strike action and ACAS talks in June 2005 — the BBC giving an undertaking that there would be no preparations made to sell the company until January 2007, and no sale allowed before July of this year. The current time-scale would see its disposal by the end of the current financial year in March 2008.

Thursday, April 6, 2006

It has been confirmed that tests done on a dead Mute Swan found in the village of Cellardyke in Fife, Scotland has tested positive for the deadly strain of H5N1 Bird Flu virus. The swan is believed to have been native to Scotland.

Two other swans found in Richmond Park in Glasgow are being tested for the H5N1 virus. They are among at least 14 other dead birds and 12 more swans found in Glasgow, that are being tested for the H5N1 virus.

This is the United Kingdom‘s first confirmed case of the H5N1 virus and would make the U.K. the 14th country to report the virus.

“The risk to humans has not changed by the fact that we have found the virus in the U.K.. There is a better chance of a person winning the national lottery than catching bird flu in the U.K. today,” said Doctor Jim Robertson from the National Institutes for Biological Standards and Control in a press conference.

“We also have to work on the assumption that there is some spread among wild birds. There is no doubt we are getting closer to the day when moving birds indoors will be necessary,” said former President of the British Veterinary Association, Bob McCracken. “The situation is that the virus is there, and it will probably continue to circulate among the birds. It will spread through close contact, irrespective of species. There is one big question mark: Will the virus disappear from wild birds after a period of six months, or will it still be present after a period of six years?” added McCracken.

McCracken also said that the virus could turn up in more birds saying, “I would start from the assumption that a small pool of wild birds in the Fife area are infected and potentially passing it on to other birds” and that seagulls could pose a threat of passing on the virus because they have been known to peck at the bodies of other dead birds that were infected. “We have to assume that,” he said.

In a statement by the Department for Environment, Food and Rural Affairs, released yesterday, the Scottish Executive confirmed that a “highly pathogenic H5 avian flu” virus was found in a sample taken from the dead swan.

The swan was discovered March 29, 2006 and has been confirmed as a domestic species and officials say that it may have caught the virus from another infected bird. Officials also report that the area where the swan has been found is being sealed off.

“In accordance with a recent EU decision the Scottish Executive is putting in place a protection zone of a minimum of three kilometres radius and a surveillance zone of 10 kilometers. Keepers of birds in the protection zone are being instructed to isolate their birds from wild birds, by taking them indoors where ever possible,” said the Scottish Executive in a statement.

Samples from the swan were sent to the European Union Bird Flu Laboratory at Weybridge.

“Bird keepers outside the protection zone should redouble their efforts to prepare for bringing their birds indoors if that becomes necessary. They must also review their biosecurity measures to ensure that all possible precautions have been taken,” said Charles Milne, Chief Veterinary Officer for Scotland yesterday in the statement.

An exercise named ‘Exercise Hawthorn’ was to prepare people for a possible pandemic was taking place yesterday and was halted just after the discovery of the dead swan. Officials were in the second phase of the exercise. Taking part in the exercises were the Ministry of Defence, the Association of Chief Police Officers, the Environment Agency and several other areas of the British government.

“I brought to an end the national avian influenza exercise to ensure that we can bring all our resources to bear on this situation. We are already in a high state of readiness and I have every confidence that officials north and south of the border will work together to manage this incident successfully,” said the United Kingdom’s Chief Veterinary Officer, Debby Reynolds.

However; today Reynolds stated “there is no reason for public health concern” and also stated that in order for Bird Flu to infect humans, it would require “extremely close contact with infected birds, particularly feces.”

According to the World Health Organization H5N1 has killed 109 people worldwide since 2003.